Key quotes:
- [The authors] analysed the phenotypic information present in large numbers of electronic medical records from the United States and Denmark to look for co-morbidities among Mendelian and complex diseases
- each complex disease was found to be associated with a unique set of Mendelian conditions.
- This finding led the authors to explore genetic models that could explain the risk of complex disease in patients with more than one Mendelian phenotype. The best explanation was provided by a model in which non-additive genetic interactions in specific 'communities' of loci have crucial roles.
What is "non-additive genetic interactions"?
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