Thursday, April 13, 2006

Joint Modeling of Linkage and Association: Identifying SNPs Responsible for a Linkage Signal

Am. J. Hum. Genet., 76:934-949, 2005
Mingyao Li, Michael Boehnke, and Gonçalo R. Abecasis

Abstract: Once genetic linkage has been identified for a complex disease, the next step is often association analysis, in which single-nucleotide polymorphisms (SNPs) within the linkage region are genotyped and tested for association with the disease. If a SNP shows evidence of association, it is useful to know whether the linkage result can be explained, in part or in full, by the candidate SNP. We propose a novel approach that quantifies the degree of linkage disequilibrium (LD) between the candidate SNP and the putative disease locus through joint modeling of linkage and association. [Read more by following the link above]

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